In case you’re wondering about how dermal fillers, such as Emervel® and Restylane® came into existence, here is a brief history of the use and advancement of dermal fillers.
It all started with fat transplants! And yes, we still do this today. Back in 1893 a Dr. Neuber was the very first doctor to attempt transplanting fat in order to fill out facial defects. Neuber would take fat from the arms to use. However, by the mid 20th century, yep you guessed it, silicone started to be investigated. Silicone was used from the 40s through the 50s, but patients would developed granulomas, small nodules of the foreign substance. This was definitely undesirable, and potentially dangerous therefore silicone was banned until 1992, until a safer form was developed.
By the 1970s, various animal collagens had been researched enough to use on humans. Collagen injections and implants were introduced. The trade names for cow derived collagen were Zyderm and Zyplast, to name a couple. The FDA first approved Zyderm, which was developed at Stanford University. But then at the beginning of this century,newer non-bovine collagen fillers were being developed, too. Meanwhile, Hyaluronic Acid fillers were being experimented with around the world. These were studied and compared to second generation non-bovine collagen in order to find which was more effective and safer. Later still, in 2006, a new family of next-generation hyaluronic acid fillers was approved by the FDA. The first one approved was Restylane®. Ultimately the synthetic fillers won out. Consequently, cosmetic surgeons now have an array of dermal fillers to choose from.
Dermal Fillers each have their place, use, and various patients have better results with different fillers. It is important to consult with your cosmetic surgeon to see which is the right one for the cosmetic procedure you want, and which is best for you personally.
Botox is purified version of a toxin, botulinum, created by a bacteria. It was first discovered by Dr. Justinus Kerner after unusual deaths in Germany after consuming sausages in the 1820’s.
The next reported cases occurred 70 years later in the 1890’s. As if a funeral is not bad enough, the next reported cases occurred when 3 people died and 23 people became paralyzed after a funeral dinner. The culprit was confirmed by Dr. Emile Pierre van Ermengem of Belgium.
Could botulinum be used as a weapon? As it is said, all is fair in love and war. In this case botulinum was going to be used in both cases. The United States produced botulinum capsules to give to Chinese prostitutes to slip into the food and drink of high ranking Japanese officers during WWII in the 1940’s. It has been said this mission was not completed.
In the 1950s Botox was purified into crystalline form that could be used in minute quantities that would be the basis for their safe use in medicine. Botox was first used in medical research in the 1970s as a safe treatment for non-invasive treatment for strabismus, “crossed eyes.” Shortly thereafter, Botox was used for the treatment of essential blepharospasm, eye spasms. After its successful use in treating these eye conditions, it use exploded into many fields in medicine including neurology, orthopaedics, ophthalmology, ENT, dermatology, and plastic surgery. Botox was finally approved by the FDA for multiple medical uses in 1989, but not for cosmetic uses.
Like many discoveries in medicine, the use of Botox to diminish wrinkles was discovered by accident in 1990. A dermatologist, Dr. Jean Carruthers, was using Botox to treat muscles in spasm around the eye, and he noticed the disappearance of the wrinkle surrounding the areas he treated and thus one of the central tools in rejuvenating the face was discovered! Botox’s use was so widespread and rapid, it briefly ran out of supply in the 1990’s.
It was not until 2002 that Botox was officially approved by the FDA for the use in the area between the eyebrows and in 2004 for treatment of excess sweating in the armpits.
To discover the cosmetic benefits of Botox, please contact Dr Paul Silvester on 07456 415251.
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